Disrupted Intercalated Discs

Disrupted intercalated discs. Is kindlin-2 required?

Intermediate filaments are cytoskeletal structures that maintain the structural and mechanical integrity of cells, tissues, and organs. These filaments are associated with the nuclear surface but extend out into the cytoplasm and interact with other cytoskeletal elements and cytoplasmic organelles. Eventually, their impingement on the plasma membrane in certain tissues allows them to be tethere...

Intercalated discs and arrhythmogenic cardiomyopathy.

Pathology of Intercalated Discs in Friedreich Cardiomyopathy.

in patients with subdural hematomas (4 of 48 patients; 8.3%) and consisted of significant increase in subdural hemorrhage with clinical deterioration; no rehemorrhages occurred in other types of intracranial hemorrhage (0 of 61 patients; 0%) (p 1⁄4 0.04). No rehemorrhages occurred in the 32 patients who had neurosurgical intervention for their initial hemorrhage, compared to 4 recurrent hemorrh...

Additional evidence for high-resistance intercalated discs in the myocardium.

TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs

Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) and vanilloid subtype-1 (TRPV1) are structurally related, non-selective cation channels that show a high permeability to calcium. Previous studies indicate that TRP channels play a prominent role in the regulation of cardiovascular dynamics and homeostasis, but also contribute to the pathophysiology of many diseases and diso...